Question 1

What causes Restless Legs Syndrome?

Accepted Answer

RLS is often related to dysfunction in how the brain processes dopamine and iron. While the exact cause can vary, low brain iron levels, certain medications, kidney disease, and pregnancy are known contributing factors. Dr. Jain conducts comprehensive testing to identify your specific triggers and address the underlying cause.

Question 2

Is Restless Legs Syndrome hereditary?

Accepted Answer

RLS can run in families, with approximately 50% of patients having a family history of the condition. Early-onset RLS (before age 40) is more likely to have a genetic component. However, not everyone with a family history will develop RLS, and the condition can also occur without any genetic predisposition.

Question 3

Can Restless Legs Syndrome be cured?

Accepted Answer

While there is no definitive cure for RLS, the condition can often be very effectively managed with proper treatment. Many patients experience significant symptom reduction through iron optimization, medication, or devices like Nidra. Dr. Jain focuses on identifying and treating underlying causes to provide long-term relief rather than just masking symptoms.

Question 4

What medications are most effective for RLS?

Accepted Answer

Dr. Jain follows the latest AASM guidelines, which prioritize alpha-2 delta ligands (like gabapentin) over older dopamine agonists that can cause augmentation. Treatment selection depends on your symptom severity, iron levels, and medical history. Some patients may benefit from combination approaches tailored to their specific situation.

Question 5

What are the side effects of RLS medications?

Accepted Answer

Side effects vary by medication class. Alpha-2 delta ligands may cause dizziness or mild sedation, while older dopamine agonists carry risks of augmentation (worsening symptoms over time) and impulse control issues. Dr. Jain carefully weighs benefits against risks and monitors patients closely to minimize adverse effects while maximizing symptom relief.

Question 6

How does the Nidra device work for RLS?

Accepted Answer

Nidra is an FDA-authorized wearable device that delivers targeted vibration therapy to the legs during sleep. It provides drug-free symptom relief for patients with moderate to severe RLS, especially those who haven't responded well to medications. The device is worn only at night and has been clinically proven to reduce RLS symptoms and improve sleep quality.

Question 7

What is the connection between iron deficiency and RLS?

Accepted Answer

Low brain iron levels can disrupt dopamine function, which is central to RLS symptoms. Many RLS patients have low ferritin (stored iron) levels even when standard blood counts appear normal. Dr. Jain checks comprehensive iron panels and may recommend iron supplementation or IV iron therapy when appropriate to address this root cause.

Question 8

Why are RLS symptoms worse at night?

Accepted Answer

RLS symptoms follow a circadian pattern, with dopamine levels naturally declining in the evening and iron transport to the brain being lowest at night. This biological rhythm explains why the urge to move your legs intensifies when you're trying to relax or sleep. Understanding this pattern helps Dr. Jain time treatments for optimal effectiveness.

Question 9

Can caffeine or alcohol make RLS worse?

Accepted Answer

Yes, both caffeine and alcohol can aggravate RLS symptoms in many patients. Caffeine may interfere with dopamine regulation, while alcohol can disrupt sleep quality and worsen symptoms during the night. Dr. Jain provides personalized guidance on dietary modifications that may help reduce symptom severity alongside medical treatment.

Restless Legs Syndrome (RLS)

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Common Questions about Restless Legs Syndrome